The Effect Of Ethanol Ants Nest Extract (Myrmecodia pendans) On Fasting Blood Sugar Levels In Mice Obesity With Type 2 Diabetes


  • Rizky Alfiqi Nuriza Department of Nutrition science, Sebelas Maret University, Surakarta, Indonesia
  • Setyo Sri Rahardjo Department of Pharmacology, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Lilik Wijayanti Clinical Pathology, Department of Faculty Medicine, Sebelas Maret University, Surakarta, Indonesia


Ants Nest, Diabetes, Ethanol Extract, Fasting Blood Sugar, Obesity


The Ant's Nest plant (Myrmecodia pendans) is known to have the potential to reduce blood glucose in obese patients with T2DM because it contains high flavonoids and tannins that can prevent oxidative stress and inhibit the work of lipase enzymes, pancreatic β cells, Glut-2 and α-glucosidase. This study aims to determine the effect of Ethanol Ants Nest Extract (Myrmecodia pendans) on changes in fasting blood glucose with T2D obesity. The type of research is true-experimental with pre-posttest control group design. This study used 30 male Wistar rats aged 8 weeks weighing 150-200 grams. The rats were divided into 6 groups, namely: KNo (normal control), KN (T2D obesity), KP (T2D obesity given metformin), P1, P2, and P3 (T2D obesity given ethanol ants nest extract 150mg/KgBW/day, 300mg/KgBW/day, and 600mg/KgBW/day for 14 days by gastric sonde). Data were analyzed using a Paired t-test and continued by using One-way ANOVA. There was a decrease in fasting blood glucose after 14 days of intervention, which was highest in the P3 group with a fasting blood sugar level of 177,534 ± 4.0 mg/dL (p < 0.0001). Giving ethanol ant nest extract has an effect in reducing fasting blood glucose levels.